MSI-H110M PRO VD in the BIOS is boot mode select [legacy + uefi], but

MSI-H110M PRO VD in the BIOS is boot mode select [legacy + uefi]

MSI-H110M PRO VD in the BIOS is boot mode select [legacy + uefi], but there is no choice of a separate legasy mode, will it start

connected hard drive that was formatted in mbr (legacy)?

This has nothing to do with the work of the hard drive, it has to do with the bootloader of the operating system, but the "legacy" systems in any case will not start if they are installed under one configuration, and then the disk is transferred to another computer - you will need to reinstall the OS.